BMX (gen)
Tampilan
Sitoplasma tyrosine protein kinase BMX adalah sebuah enzim yang pada manusia dikodekan oleh gen BMX.[4][5]
Fungsi
[sunting | sunting sumber]Tirosin kinase bisa berupa reseptor molekul-molekul yang mengandung transmembran dan domain ekstraseluler, atau nonreceptor protein, yang tersusun secara intraselular. Satu keluarga nonreceptor TKs meliputi gen TEC, TXK, ITK, dan BTK. Semua protein ini homolognya dari Drosophila Src28 TK dan mengandung SH3 dan SH2 domain hulu dari domain TK.
Interaksi
[sunting | sunting sumber]BMX telah terbukti berinteraksi dengan:
Referensi
[sunting | sunting sumber]- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000031377 - Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Tamagnone L, Lahtinen I, Mustonen T, Virtaneva K, Francis F, Muscatelli F, Alitalo R, Smith CI, Larsson C, Alitalo K (December 1994). "BMX, a novel nonreceptor tyrosine kinase gene of the BTK/ITK/TEC/TXK family located in chromosome Xp22.2". Oncogene. 9 (12): 3683–8. PMID 7970727.
- ^ "Entrez Gene: BMX BMX non-receptor tyrosine kinase".
- ^ Bagheri-Yarmand R, Mandal M, Taludker AH, Wang RA, Vadlamudi RK, Kung HJ, Kumar R (August 2001). "Etk/Bmx tyrosine kinase activates Pak1 and regulates tumorigenicity of breast cancer cells". J. Biol. Chem. 276 (31): 29403–9. doi:10.1074/jbc.M103129200. PMID 11382770.
- ^ Chen R, Kim O, Li M, Xiong X, Guan JL, Kung HJ, Chen H, Shimizu Y, Qiu Y (May 2001). "Regulation of the PH-domain-containing tyrosine kinase Etk by focal adhesion kinase through the FERM domain". Nat. Cell Biol. 3 (5): 439–44. doi:10.1038/35074500. PMID 11331870.
- ^ Jui HY, Tseng RJ, Wen X, Fang HI, Huang LM, Chen KY, Kung HJ, Ann DK, Shih HM (December 2000). "Protein-tyrosine phosphatase D1, a potential regulator and effector for Tec family kinases". J. Biol. Chem. 275 (52): 41124–32. doi:10.1074/jbc.M007772200. PMID 11013262.
- ^ Yang J, Kim O, Wu J, Qiu Y (August 2002). "Interaction between tyrosine kinase Etk and a RUN domain- and FYVE domain-containing protein RUFY1. A possible role of ETK in regulation of vesicle trafficking". J. Biol. Chem. 277 (33): 30219–26. doi:10.1074/jbc.M111933200. PMID 11877430.
Pranala luar
[sunting | sunting sumber]- Manusia Lokasi genom BMX manusia dan halaman rincian gen BMX dalam UCSC Genome Browser.UCSC Genome BrowserLokasi genom BMX manusia dan halaman rincian gen BMX dalam UCSC Genome Browser.