HIV-1 protease
| HIV-1 Protease (Retropepsin) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 Dimer HIV-1 protease dengan warna putih dan kelabu; substrat peptida diwarnai hitam dan situs aktif rantai samping aspartat diwarnai merah. (PDB: 1KJF) | |||||||||
| Pengidentifikasi | |||||||||
| Nomor EC | 3.4.23.16 | ||||||||
| Nomor CAS | 144114-21-6 | ||||||||
| Basis data | |||||||||
| IntEnz | tinjauan IntEnz | ||||||||
| BRENDA | entri BRENDA | ||||||||
| ExPASy | tinjauan NiceZyme | ||||||||
| KEGG | entri KEGG | ||||||||
| MetaCyc | jalur metabolik | ||||||||
| PRIAM | profil | ||||||||
| Struktur PDB | RCSB PDB PDBe PDBsum | ||||||||
| Ontologi Gen | AmiGO / EGO | ||||||||
| |||||||||
HIV-1 protease (PR) adalah sebuah enzim protease aspartat retrovirus (retropepsin), yang terlibat dalam hidrolisis ikatan peptida dalam retrovirus, dan merupakan enzim penting daram siklus hidup HIV (retrovirus penyebab AIDS).[1][2] HIV protease memutus poliprotein Gag dan Gag-Pol[3] yang baru disintesis pada sembilan titik berbeda untuk menghasilkan komponen-komponen protein yang membentuk virion HIV. Tanpa HIV protease yang bekerja dengan baik, partikel-partikel virus HIV tidak dapat menginfeksi sel.[4][5][6]
Referensi
[sunting | sunting sumber]- ^ Davies DR (1990). "The structure and function of the aspartic proteinases". Annual Review of Biophysics and Biophysical Chemistry. 19 (1): 189–215. doi:10.1146/annurev.bb.19.060190.001201. PMID 2194475. Diarsipkan dari versi asli tanggal 2022-09-14. Diakses tanggal 2020-03-29.
- ^ Brik A, Wong CH (January 2003). "HIV-1 protease: mechanism and drug discovery". Organic & Biomolecular Chemistry. 1 (1): 5–14. doi:10.1039/b208248a. PMID 12929379.
- ^ Huang X, Britto MD, Kear-Scott JL, Boone CD, Rocca JR, Simmerling C, Mckenna R, Bieri M, Gooley PR, Dunn BM, Fanucci GE (June 2014). "The role of select subtype polymorphisms on HIV-1 protease conformational sampling and dynamics". The Journal of Biological Chemistry. 289 (24): 17203–14. doi:10.1074/jbc.M114.571836. PMC 4059161
. PMID 24742668.
- ^ Lv Z, Chu Y, Wang Y (April 2015). "HIV protease inhibitors: a review of molecular selectivity and toxicity". HIV/AIDS: Research and Palliative Care (dalam bahasa English). 7: 95–104. doi:10.2147/hiv.s79956. PMC 4396582 . PMID 25897264.
- ^ Kräusslich HG, Ingraham RH, Skoog MT, Wimmer E, Pallai PV, Carter CA (February 1989). "Activity of purified biosynthetic proteinase of human immunodeficiency virus on natural substrates and synthetic peptides". Proceedings of the National Academy of Sciences of the United States of America. 86 (3): 807–11. Bibcode:1989PNAS...86..807K. doi:10.1073/pnas.86.3.807. PMC 286566 . PMID 2644644.
- ^ Kohl NE, Emini EA, Schleif WA, Davis LJ, Heimbach JC, Dixon RA, Scolnick EM, Sigal IS (July 1988). "Active human immunodeficiency virus protease is required for viral infectivity". Proceedings of the National Academy of Sciences of the United States of America. 85 (13): 4686–90. Bibcode:1988PNAS...85.4686K. doi:10.1073/pnas.85.13.4686. PMC 280500 . PMID 3290901.
