Metdilazin

Metdilazin

Nama sistematis (IUPAC)
10-[(1-metilpirolidin-3-il) metil]- 10H-fenotiazina
Data klinis
AHFS/Drugs.com	monograph
Kat. kehamilan	?
Status hukum	?
Pengenal
Nomor CAS	1982-37-2 Y
Kode ATC	R06AD04
PubChem	CID 14677
Ligan IUPHAR	7231
DrugBank	DB00902
ChemSpider	14009 Y
UNII	4Q13LY9Z8X Y
KEGG	D04979 Y
ChEBI	CHEBI:6823
ChEMBL	CHEMBL1200959 N
Data kimia
Rumus	C18H20N2S
SMILES	eMolecules & PubChem
InChI InChI=1S/C18H20N2S/c1-19-11-10-14(12-19)13-20-15-6-2-4-8-17(15)21-18-9-5-3-7-16(18)20/h2-9,14H,10-13H2,1H3 Y Key:HTMIBDQKFHUPSX-UHFFFAOYSA-N Y

Metdilazin adalah antihistamin generasi pertama dengan sifat antikolinergik dari kelas fenotiazin.

Sintesis

Sintesis metdilazin: R. F. Feldkamp and Y. H. Wu; Mead Johnson & Company; Templat:US Patent (1960).

Bacaan lebih lanjut

• Rani Basu L, Mazumdar K, Dutta N, Karak P, Dastidar S (2005). "Antibacterial property of the antipsychotic agent prochlorperazine, and its synergism with methdilazine". Microbiol Res. 160 (1): 95–100. doi:10.1016/j.micres.2004.10.002 . PMID 15782943. 
• Chattopadhyay D, Mukherjee T, Pal P, Saha B, Bhadra R (1998). "Altered membrane permeability as the basis of bactericidal action of methdilazine". J Antimicrob Chemother. 42 (1): 83–6. doi:10.1093/jac/42.1.83 . PMID 9700532. 
• Chattopadhyay D, Dastidar S, Chakrabarty A (1988). "Antimicrobial properties of methdilazine and its synergism with antibiotics and some chemotherapeutic agents". Arzneimittelforschung. 38 (7): 869–72. PMID 2905130.