Oksifenbutazon

Oksifenbutazon
Nama sistematis (IUPAC)
	(RS)-4-butil-1-(4-hidroksifenil)-2-fenilpirazolidina-3,5-diona
Data klinis
Nama dagang	Tandearil, Tanderil
AHFS/Drugs.com	International Drug Names
Kat. kehamilan	?
Status hukum	? (AU) ? (UK)
Pengenal
Nomor CAS	129-20-4
Kode ATC	M01AA03 M02AA04 S01BC02
PubChem	CID 104811
DrugBank	DB03585
ChemSpider	94610
UNII	A7D84513GV
KEGG	D08324
ChEBI	CHEBI:76258
ChEMBL	CHEMBL1228
Data kimia
Rumus	C19H20N2O3
SMILES	eMolecules & PubChem
	InChI InChI=1S/C19H20N2O3.H2O/c1-2-3-9-17-18(23)20(14-7-5-4-6-8-14)21(19(17)24)15-10-12-16(22)13-11-15;/h4-8,10-13,17,22H,2-3,9H2,1H3;1H2 ; Key:CNDQSXOVEQXJOE-UHFFFAOYSA-N ;

Oksifenbutazon adalah obat antiinflamasi nonsteroid (OAINS).^[1] Obat ini merupakan metabolit dari fenilbutazon.^[2]

Obat ini ditarik dari pasaran di seluruh dunia pada pertengahan tahun 1980-an karena dapat menekan fungsi sumsum tulang dan menimbulkan risiko sindrom Stevens-Johnson.^[3]^[4]

Masyarakat dan budaya

Dalam permainan Scrabble, kata oxyphenbutazone adalah kata dengan skor tertinggi saat ini yang menghasilkan 1.780 poin berdasarkan daftar kata NASPA tahun 2006.^[5]

Referensi

^ Singh N, Jabeen T, Somvanshi RK, Sharma S, Dey S, Singh TP (November 2004). "Phospholipase A2 as a target protein for nonsteroidal anti-inflammatory drugs (NSAIDS): crystal structure of the complex formed between phospholipase A2 and oxyphenbutazone at 1.6 A resolution". Biochemistry. 43 (46): 14577–83. doi:10.1021/bi0483561. PMID 15544328.
^ Matthews NS, Peck KE, Taylor TS, Mealey KL (May 2001). "Pharmacokinetics of phenylbutazone and its metabolite oxyphenbutazone in miniature donkeys". American Journal of Veterinary Research. 62 (5): 673–5. doi:10.2460/ajvr.2001.62.673 . PMID 11341383.
^ Fung M, Thornton A, Mybeck K, Wu JH, Hornbuckle K, Muniz E (January 2001). "Evaluation of the Characteristics of Safety Withdrawal of Prescription Drugs from Worldwide Pharmaceutical Markets-1960 to 1999". Therapeutic Innovation & Regulatory Science. 35 (1): 293–317. doi:10.1177/009286150103500134.
^ Biron P (May 1986). "Withdrawal of oxyphenbutazone: what about phenylbutazone?". CMAJ. 134 (10): 1119–20. PMC 1491052 . PMID 3697857.
^ Wood, Dave (22 May 2008). "Record for the Highest Scoring Scrabble Move". Scrabulizer. Diarsipkan dari versi asli tanggal 11 May 2023.

Artikel bertopik farmasi ini adalah sebuah rintisan. Anda dapat membantu Wikipedia dengan mengembangkannya.

[1] Singh N, Jabeen T, Somvanshi RK, Sharma S, Dey S, Singh TP (November 2004). "Phospholipase A2 as a target protein for nonsteroidal anti-inflammatory drugs (NSAIDS): crystal structure of the complex formed between phospholipase A2 and oxyphenbutazone at 1.6 A resolution". Biochemistry. 43 (46): 14577–83. doi:10.1021/bi0483561. PMID 15544328.

[2] Matthews NS, Peck KE, Taylor TS, Mealey KL (May 2001). "Pharmacokinetics of phenylbutazone and its metabolite oxyphenbutazone in miniature donkeys". American Journal of Veterinary Research. 62 (5): 673–5. doi:10.2460/ajvr.2001.62.673 . PMID 11341383.

[Fung-2001-3] Fung M, Thornton A, Mybeck K, Wu JH, Hornbuckle K, Muniz E (January 2001). "Evaluation of the Characteristics of Safety Withdrawal of Prescription Drugs from Worldwide Pharmaceutical Markets-1960 to 1999". Therapeutic Innovation & Regulatory Science. 35 (1): 293–317. doi:10.1177/009286150103500134.

[4] Biron P (May 1986). "Withdrawal of oxyphenbutazone: what about phenylbutazone?". CMAJ. 134 (10): 1119–20. PMC 1491052 . PMID 3697857.

[5] Wood, Dave (22 May 2008). "Record for the Highest Scoring Scrabble Move". Scrabulizer. Diarsipkan dari versi asli tanggal 11 May 2023.

[1]

[2]

[3]

[4]

[5]