Sinkokain

Sinkokain
Nama sistematis (IUPAC)
	2-butoksi-N-[2-(dietilamino)etil]kuinolina-4-karboksamida
Data klinis
AHFS/Drugs.com	International Drug Names
Kat. kehamilan	?
Status hukum	OTC (US)
Rute	topikal, intravena (untuk eutanasia hewan)
Pengenal
Nomor CAS	85-79-0
Kode ATC	C05AD04 D04AB02 N01BB06 S01HA06 S02DA04
PubChem	CID 3025
Ligan IUPHAR	7159
DrugBank	DB00527
ChemSpider	2917
UNII	L6JW2TJG99
KEGG	D00733
ChEBI	CHEBI:247956
ChEMBL	CHEMBL1086
Data kimia
Rumus	C20H29N3O2
SMILES	eMolecules & PubChem
	InChI InChI=1S/C20H29N3O2/c1-4-7-14-25-19-15-17(16-10-8-9-11-18(16)22-19)20(24)21-12-13-23(5-2)6-3/h8-11,15H,4-7,12-14H2,1-3H3,(H,21,24) ; Key:PUFQVTATUTYEAL-UHFFFAOYSA-N ;

Sinkokain (INN/BAN) atau dibukain (USAN) adalah anestesi lokal golongan Amida. Di antara obat anestesi lokal jangka panjang yang paling ampuh dan beracun, penggunaan sinkokain saat ini umumnya terbatas pada anestesi tulang belakang dan topikal.^[1]^[2]

Kegunaan dalam Medis

Sinkokain adalah bahan aktif dalam beberapa krim bawasir topikal.^[3] Obat ini juga merupakan komponen obat hewan "Somulose", yang digunakan untuk eutanasia kuda dan sapi.

Properti Fisik

Sinkokain relatif tidak larut dalam larutan berair alkali.

Referensi

^ Martindale, The Extra Pharmacopoeia, 30th ed, p1006
^ "Dibucaine". MeSH Browser. U.S. National Library of Medicine.
^ Henderson R (29 November 2020). "Proctosedyl ointment/suppositories (cinchocaine, hydrocortisone)". Netdoctor. Diakses tanggal 25 December 2019.

Bacaan Lebih Lanjut

Abdel-Ghani NT, Youssef AF, Awady MA (May 2005). "Cinchocaine hydrochloride determination by atomic absorption spectrometry and spectrophotometry". Farmaco. 60 (5): 419–424. doi:10.1016/j.farmac.2005.03.001. PMID 15910814.
Souto-Padrón T, Lima AP, Ribeiro Rd (September 2006). "Effects of dibucaine on the endocytic/exocytic pathways in Trypanosoma cruzi". Parasitology Research. 99 (4): 317–320. doi:10.1007/s00436-006-0192-1. PMID 16612626.
Nounou MM, El-Khordagui LK, Khalafallah N (2005). "Effect of various formulation variables on the encapsulation and stability of dibucaine base in multilamellar vesicles". Acta Poloniae Pharmaceutica. 62 (5): 369–379. PMID 16459486.
Aroti A, Leontidis E (2001). "Simultaneous Determination of the Ionization Constant and the Solubility of Sparingly Soluble Drug Substances. A Physical Chemistry Experiment". Journal of Chemical Education. 78 (6): 786–788. Bibcode:2001JChEd..78..786A. doi:10.1021/ed078p786.

[1] Martindale, The Extra Pharmacopoeia, 30th ed, p1006

[2] "Dibucaine". MeSH Browser. U.S. National Library of Medicine.

[Netdoctor-3] Henderson R (29 November 2020). "Proctosedyl ointment/suppositories (cinchocaine, hydrocortisone)". Netdoctor. Diakses tanggal 25 December 2019.

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[2]

[3]